Primoz Roglic's withdrawal from the Vuelta a Espana is a huge disappointment for Enric Mas, as he aims to chase down Remco Evenepoel in the final stages of the race.

Three-time reigning champion Roglic crashed just before the line on Tuesday, having looked set to take the lead off Evenepoel, who has now held the red jersey for 12 stages of this year's event.

Roglic's chances of an unprecedented fourth straight Vuelta title are now over after the Slovenian elected to withdraw from the race, leaving Mas as Evenepoel's closest rival.

Yet the Spaniard was unable to close the gap on Wednesday as Evenepoel and his Quick-Step Alpha Vinyl team managed the red jersey group, with both riders collecting the same time after a 162-kilometre route from Aracena to Monasterio de Tentudia.

Rigoberto Uran claimed a breakaway win, sealing his first individual success at La Vuelta, meaning the 35-year-old has now won a stage at each of the Grand Tours.

Jesus Herrada led until just before the finish, with Uran timing his final attack to perfection to hold off Quentin Pacher and become the fourth different Colombian rider to win a stage at La Vuelta since the start of the 2019 edition.

Mas had to settle for 15th, one place behind Evenepoel, and knows his Movistar team will have to come up with something special to topple the Belgian in the race's final days.

"We go day by day, I think every day is super important. Yesterday you all saw the crash of Primoz. We need to be very focused," Mas said. "It's not nice when somebody crashes. He's a super rider, a super good person. I think it's s*** that Roglic is not here anymore.

"I don't know what we're going to do tomorrow, but if we have good legs and a good feeling, and the atmosphere in the team is super good, we have to do something, no?"

Evenepoel betters Merckx 

He may hold a lead of over two minutes, but Evenepoel is not taking anything for granted, and delivered an expertly controlled ride to keep his rivals at bay.

"Pretty tough, it was not easy at all. Especially the run-in was really nervous and also a big road going quite steep. It looked easier on television than it was in real life," he said.

Evenepoel is the first rider to lead La Vuelta for 12 consecutive stages since 2019, when Roglic led for the final 12. The 22-year-old has now overtaken the great Eddy Merckx as fourth on the list of Belgians with the most days leading the race, after Gustaaf Deloor (32), Freddy Maertens (22) and Rick van Looy (13).

STAGE RESULT

1. Rigoberto Uran (EF Education–EasyPost) 3:42:28
2. Quentin Pacher (Groupama-FDJ) same time
3. Jesus Herrada (Cofidis) +0:02
4. Marc Soler (UAE Team Emirates) +0:15
5. Kelly Elissonde (Trek-Segafredo) +0:26

CLASSIFICATION STANDINGS

General Classification

1. Remco Evenepoel (Quick-Step Alpha Vinyl) 65:14:05
2. Enric Mas (Movistar) +2:01
3. Juan Ayuso (UAE Team Emirates) +4:51

Points Classification

1. Mads Pedersen (Trek-Segafredo) 349
2. Fred Wright (Bahrain Victorious) 149
3. Marc Soler (UAE Team Emirates) 133

King of the Mountains

1. Jay Vine (Alpecin-Deceuninck) 59
2. Richard Carapaz (INEOS Greandiers) 30
3. Thymen Arensman (Team DSM) 22

The Buffalo Bills are a team who have come to be defined by the agony they have suffered.

Though they are responsible for one of the most dominant stretches of offensive football in NFL history in the late 1980s and early 1990s and have more recently re-emerged as one of the most exciting teams in the league, the Bills are still yet to experience the ultimate glory of lifting the Vince Lombardi Trophy. 

Buffalo finished in the top seven for yards and points every year between 1989 and 1993 as the Bills' K-Gun offense illustrated just how devastating a no-huddle attack could be. Yet Marv Levy's star-studded group is best remembered for losing four successive Super Bowls between 90 and 93.

And Bills fans would be forgiven for pessimistically thinking the Josh Allen era is doomed to end without a first Super Bowl win in franchise history.

Allen has silenced critics who doubted his ability to improve his accuracy to become one of the most dynamic quarterbacks in the modern NFL, and the Bills have been in the top five in offensive yards and points in each of the last two seasons.

However, those campaigns have both delivered heartbreaking playoff losses to the Kansas City Chiefs, the Bills on the wrong end of one of arguably the finest postseason game in NFL history, losing 42-36 having allowed the Chiefs to drive for a game-tying field goal in the final 13 seconds of regulation.

The Four Falls of Buffalo, as they were labelled in a 30 for 30 documentary about the Super Bowl losses, and '13 seconds' will forever live in franchise infamy.

But the Bills head into 2022 with a case for being the strongest team in the league. So, as they prepare to face the defending Super Bowl-champion Los Angeles Rams in Thursday's mouth-watering season opener, how can Allen and Co. soothe the wounds of those missed opportunities by finally getting over the hump this season?
 

Taking the pressure off Allen

It may be a perplexing statement to read given Allen is fifth in passing yards (8,951) and fourth in passing touchdowns (73) over the past two seasons, but the Bills could maximise the impact of having the luxury of a quarterback of his talents by taking some of the pressure off his shoulders.

Buffalo's front office appeared to realise that this offseason, selecting running back James Cook in the second round of the draft.

Cook's burst through the running lane and up to the second level makes him an ideal fit for an offense that has found success with outside zone run concepts.

The Bills called outside zone on 21.26 per cent of their run plays last year, above the NFL average of 19.1. They put up 4.51 yards per play on such runs, again better than the league-wide average of 4.32.

Cook is a home-run hitter who can weaponise the threat of such runs in a way Devin Singletary and Zack Moss cannot. The Bills had 60 runs of 10 yards or more in 2021, the seventh-most in the NFL, but 28 of them came from QB Allen (Singletary had 20 while Moss delivered only six).

Should Cook's 4.4 speed translate to the pros, the Bills would have a back with the skill set to allow them to increase their menu of wide zone runs and make the zone-read more of a weapon. Despite the threat of Allen as a runner, the Bills averaged just 3.67 yards per play on zone-reads last season.

The Bills turned to run game on only 34.7 per cent of offensive snaps in 2021 and, when they did, the ball frequently remained in the hands of Allen, who has carried the ball 422 times since entering the NFL in 2018, a number second only to that of Lamar Jackson (615) among quarterbacks. Last season accounted for 122 of thsoe, with Jackson (133) and Jalen Hurts (139) the two signal-callers to attempt more runs.

Cook's arrival can take some of the onus off Allen as a runner, while the former Georgia back will hope to give his QB a few more easy buttons in the passing game.

His average of 10.9 yards per reception in a college career that spanned from 2018 to 2021 was seventh in the Power 5 in that time and first in the SEC, while Cook also racked up 11 receptions of at least 10 yards in 2021, tied for 12th among Power 5 backs.

Playing in an offense that has seen Allen consistently push the ball downfield -- Derek Carr (72) and Russell Wilson (70) were the only two quarterbacks to attempt more passes of at least 21 air yards last year than Allen's 68 -- Cook should have substantial space in underneath areas to exploit as a receiver.

If Allen takes advantage of those high-percentage throws when they come available, it will decrease the pressure on him to make the highlight reel passes to which the NFL universe has become accustomed, yet potential improvements in his accuracy could also have a massive bearing on his and the Bills' success in 2022.
 

Allen's extra 1%

Across the Wild Card Round of the playoffs, in which the Bills did not punt and scored a touchdown on every drive against the New England Patriots, and his equally remarkable performance in the '13 seconds game', Allen completed 77.4 per cent of his passes for 637 yards, nine touchdowns and zero interceptions.

He averaged 10.27 yards per attempt and had a passer rating of 149.0 in an incredible finale to a campaign that makes talk of finding areas for improvement seem bizarre.

Yet the best athletes are always striving to find that extra one per cent and Allen looks to have indentified where his potentially lies.

"I think, myself especially, making sure I'm on time, making the right reads and giving our guys good enough balls to get some some more RAC [run after catch]," Allen said during the offseason.

"That's one thing I think, on offense, run after catch was wasn't very high last year, but again, that's me putting the ball where it needs to be and allow our guys to catch in a good position to make a run after the catch.

"So working on that, that's been been one of my biggest takeaways in this offseason and trying to work on just ball placement and allowing our receivers to do that."

Allen's assessment is backed up by the numbers. Among 31 qualifying quarterbacks, Allen was last in yards after catch per reception with an average of just 4.5 in a season where his well-thrown percentage dropped significantly.

In his breakout 2020 season, Allen produced an accurate, well-thrown ball on 80.5 per cent of his pass attempts, the seventh-best ratio among quarterbacks with at least 100 attempts. Last season, his well-thrown rate fell to 77.2, below the league average of 78.1 for signal-callers to reach three figures in attempts.

Though the difference in his YAC per reception was negligible -- Allen averaged 4.6 per completed pass in 2020 -- there is no doubt the Bills' offense would benefit from him rediscovering the accuracy of two seasons ago.

Emmanuel Sanders and Cole Beasley have departed, but Stefon Diggs and the emerging Gabriel Davis represent two top two pass-catching weapons for Allen, and he also has two new targets for 2022 who should each thrive if he can do a better job leading his receivers.

Veteran Jamison Crowder has averaged 4.6 yards after catch per reception since 2019, almost a full yard more than Diggs (3.7) and rookie fifth-round pick Khalil Shakir possesses the vision, fluidity and love of contact to excel with the ball in his hands.

Allen improving his anticipation will go a long way to helping the Bills meet the expectations they face in 2022, but he could still use a helping hand from a loaded defense that was not without its own imperfections last year.
 

A more prolific pass rush

The Billls' headline addition of the offseason was that of Von Miller, the veteran edge rusher who arrived after displaying the plentiful amount of fuel he still has in the tank during a sojourn with the Los Angeles Rams that ended with his second Super Bowl title.

Miller finished the season with a stunt-adjusted pass rush win rate of 43.4 per cent, which was the fifth-highest among edge rushers with at least 100 one on one matchups.

Between Week 15 of the regular season and the Rams' Super Bowl triumph, Miller racked up nine sacks. Only in the NFC Championship Game against the San Francisco 49ers did he fail to bring down the quarterback.

No surprise then, that Miller's acquisition sees the Bills pass rush enter the season fourth in Stats Perform's postional rankings.

Justifying that ranking is another matter, however.

The Bills did an excellent job of pressuring opposing quarterbacks last season, in which they were sixth in pass rush win rate. Yet there is clear room for improvement in converting those pressures into sacks. Buffalo registered 42 sacks in 2021, 39 of them for negative yardage - that latter number good enough for 12th in the NFL.

Buffalo will look for Miller to vastly improve the Bills' ability to turn pressures into negative plays, though the former Denver Bronco cannot do it alone. Gregory Rousseau, Carlos 'Boogie Basham' and A.J. Epenesa all had pressure rates below 17 per cent last season as the trio of edge rushers selected highly by the Bills over the course of the last two years struggled to justify their respective draft statuses. On the interior, Ed Oliver has never had more than five sacks since being picked in the top 10 in 2019.

It was in the Divisional Round where the Bills need for extra pass-rush help was encapsulated. Buffalo pressured Patrick Mahomes 23 times but registered just two sacks.

Any kind of disruption is production when it comes to the pass rush. Pressure often leads to critical mistakes, but the likes of Mahomes and his contemporaries have grown so adept at dealing with it - Mahomes threw just five interceptable passes on 194 attempts under duress last season - that is simply not enough to get into the backfield and expect bad results for the offense.

Simply put, the Bills must do a better job of ensuring their successful pass rushes pay dividends and consistently put opposing aerial attacks in disadvantageous situations

Success in doing so would improve the odds of an extremely talented secondary surviving cornerback Tre'Davious White's early-season absence and create more chances for an opportunistic defense to produce turnovers going up against offenses working from behind the chains.

The Bills' inconsistency in turning pressure into sacks, their need for more YAC and perhaps a less Allen-centric run game are all minor blemishes for arguably the most complete team in the NFL.

Yet small issues can quickly become significant problems in the spotlight of the postseason, and it would grealy behove the Bills to iron out the imperfections that could impact their hopes of finally ending their tortuous wait for a title.

Anthony Joshua's promoter Eddie Hearn has declared his fighter has accepted a proposed bout with Tyson Fury.

The Gypsy King went public with his proposal to Joshua as he pushes to set up a 'Battle of Britain' clash with the WBC heavyweight belt on the line before the end of 2022.

Fury and Joshua had an agreement to fight in Saudi Arabia in August 2021 but those plans came crashing down after a judge ordered Deontay Wilder to be granted his rematch with Fury.

But now the fight looks likely to go ahead, and is set to be held in the UK, after Hearn confirmed an offer has been accepted.

"We offered Tyson Fury the fight when he wasn't champion, at 60-40, and he turned it down; he asked for 50-50," he told IFL TV.

"I spoke to AJ [this time], and he said, 'Look, I don't believe he's for real, but yeah, I'll take the fight. See what the offer is'.

"They came back yesterday, and me and George [Warren] kind of had an agreement that we weren't gonna talk about it, but obviously Fury came out and basically let the world know the offer.

"Sixty-forty was the offer, as Tyson said. They want a rematch clause, and they asked for a date at the beginning of November [for the initial fight]. 

"I don't know whether that was a wind-up or whatever, but we just went back this morning and said: 'We think, I think particularly, he deserves more than 40 per cent, but he's happy. And I don't make the decisions, he does'.

"So, I went back this morning and said: 'We accept 60-40, we want that reversed in a rematch, rightfully so. [Fury is] the champion here, you want the biggest split, which I think is fair - and we want to do the fight in December'." 

Fury said on Wednesday that his team had secured provisional dates for Wembley and Cardiff, with Hearn suggesting December 17 as a good option for the bout.

Hearn added: "Interestingly, they have [a date booked for] 17 December held at [what was formerly] Millenium Stadium, so that's perfect. That's perfect for us."

The idea of "any given Sunday" is what makes the NFL so compelling.

Any one team can beat another, and that means at this stage of the season, with the first snap still to be taken, every team can have Super Bowl aspirations.

Sort of.

The Cincinnati Bengals, for example, may have been slightly surprising contenders in 2021, but there remain some teams whose title hopes are so remote as to be non-existent.

For some, this is because they have missed their shot at glory in recent years; for others, the plan is to challenge in seasons to come.

So, this leads us to draw up a preseason tier system, ranking all 32 teams by their Super Bowl windows with the help of Stats Perform AI predictions...

Nowhere near

This is unlikely to be a season to remember for the teams grouped in this category, for a variety of reasons.

The Houston Texans won the AFC South in 2018 and 2019, but the Deshaun Watson saga and two down years have them looking at a rebuild, with the data forecasting just 4.8 wins this year. That at least ranks them ahead of the Atlanta Falcons (3.6 projected wins) and the New York Giants (4.2), while the Texans did gain draft assets in the Watson trade.

The Chicago Bears are the fourth and final team projected to earn fewer than six wins (4.9), with second-year quarterback Justin Fields receiving little help on offense and playing behind an offensive line ranked 31st in pass protection.

Meanwhile, the Washington Commanders rank 31st in terms of skill players – better only than the Falcons – with faith in Carson Wentz long since having diminished. In Baker Mayfield and Sam Darnold, the Carolina Panthers have two high-draft-pick QBs unlikely to trouble the postseason. The New York Jets are in a similar boat, even if Zach Wilson is still young.

The Detroit Lions might argue they do not deserve to keep such company after a 3-3 finish to last season, but nobody could seriously argue they are title contenders.

Entering contention

If that first group was a mixed bag, so too is the second.

Anyone who has paid any attention to the New England Patriots' preseason would suggest they are very fortunate to be given any hope of success in the near future, but they finished with 10 wins in 2021 – even if that number is projected to shrink to 7.7. Despite a trade for Tyreek Hill, that still ranks the Patriots comfortably ahead of the Miami Dolphins (7.0), although the losing team in their Week 1 meeting will face a long slog of a season.

At the other end of the spectrum, the Philadelphia Eagles are forecast to have 11.9 wins – the second-most in the NFL – after a very strong offseason. But Jalen Hurts, for now, is unproven in the postseason, so Philly fans may have to stay patient.

The San Francisco 49ers are even younger at QB after promoting Trey Lance to a starting role, which explains why the prediction model looks so unfavourably on a team many consider contenders right now. Just 7.1 projected wins speaks to the potentially low floor Lance brings.

NFC West rivals the Arizona Cardinals have to be considered among this group of future hopefuls, with Kyler Murray hugely talented and now committed long term but frustratingly inconsistent, while the Jacksonville Jaguars will hope Trevor Lawrence can follow in the footsteps of the Bengals' Joe Burrow – the number one pick the year before him.

The Los Angeles Chargers, with 9.8 projected wins, have Justin Herbert to lead their charge, while the Cleveland Browns might have been contenders already if not for Watson's suspension, which is enough to limit them to a still strong 9.3-win forecast.

In their prime

The Chargers may have Herbert, but they also have three division rivals who intend to win and intend to win now. Indeed, all four AFC West teams rank in the top half of the league in terms of projected wins, with the Chargers second – behind the Kansas City Chiefs (11.5) and just ahead of the Denver Broncos (9.7) and the Las Vegas Raiders (9.2).

The Chiefs lead the AFC in this regard, although their playoff win over the Buffalo Bills last season came down to a coin flip, and the two are set to be similarly tough to separate this year. Buffalo are down for 11.1 wins.

The two teams coming off a Super Bowl run are of course prominent among the contenders, even if the model has far greater optimism for a Los Angeles Rams repeat than for another Bengals charge. The Rams are backed for a league-leading 12.4 wins and given a 15.3 per cent shot at defending their title, while the Bengals are actually projected to dip below .500 with 8.2 wins.

The Bengals' route to the Super Bowl will be complicated not just by the AFC West and the Bills but also by any return to form for the fit-again Lamar Jackson's Baltimore Ravens, who are counted among nine teams on course for 10 or more wins (10.4).

Also in that group are NFC pair the Dallas Cowboys (11.0) and the Minnesota Vikings (10.9), who may not even be the best teams in their divisions but might be nearing a point when they must seriously challenge or start again, which brings us to...

Last chance saloon

As long as Tom Brady and Aaron Rodgers are the QBs for the Tampa Bay Buccaneers and the Green Bay Packers, those teams are in with a chance. The question is how long that will remain the case.

Brady is 45, briefly retired this offseason and then missed a chunk of the preseason. Rodgers is 38, has repeatedly been linked with a move away from Green Bay and lost top target Davante Adams ahead of the new season. Still, the Buccaneers rank eighth for projected wins (10.7), with the Packers up in third (11.5).

They are not the only ageing teams in the NFL, however.

The Indianapolis Colts hope they have upgraded in moving from Wentz to Matt Ryan, yet the former MVP is now 37 and last played in the postseason in 2017 – when Wentz's Eagles took the title.

Tennessee Titans QB Ryan Tannehill is a little younger at 34, but of greater concern would be Derrick Henry's durability after the injury that limited to eight games last regular season. The Titans need to make the most of any seasons they have left of the superstar running back going at full tilt.

Missed their chance

Russell Wilson, Ben Roethlisberger and Drew Brees won Super Bowls with the Seattle Seahawks, the Pittsburgh Steelers and the New Orleans Saints respectively, but with all three having now moved on, it is difficult to see those teams plotting a path to the title.

For the Seahawks and the Steelers, this will be their first year without their stalwart QBs, even if things had already gone stale in 2021. Wilson dipped below the .500 mark for a season for the first time in his career, while Pittsburgh were attempting to stay competitive in spite of Roethlisberger rather than because of him.

Still, with both gone – Wilson to Denver and Roethlisberger to retirement – there is a void under center that has not been suitably filled. Seattle also rank 32nd in pass protection, likely leaving Geno Smith hopelessly exposed.

The Saints have had another 12 months to come to terms with Brees' exit, albeit they spent it juggling Jameis Winston, Trevor Siemian and Taysom Hill at QB. Winston's season-ending injury doomed the Saints' hopes of contention last year, and New Orleans' outlook for 9.5 wins with the entertaining but erratic former number one pick is at least far more positive than that of the Seahawks (6.2) or the Steelers (7.0).

Regardless, each of these three teams have provided an example in how not to do succession planning. They all could have won additional honours with their departed veterans and now face long waits for further title tilts.

Tyson Fury has claimed his team has provisionally booked dates at Wembley and Cardiff for a potential 'Battle of Britain' clash with Anthony Joshua, with a date at Manchester United's Old Trafford seen as "too short".

The WBC heavyweight champion has laid down the mantle to his compatriot in attempts to finally give fans the fight they have been crying out for, although not with the same stakes as previously anticipated.

Fury and Joshua had an agreement to fight in Saudi Arabia in August 2021, which would have been a unification of the three leading heavyweight titles, but plans collapsed after a US judge ruled Deontay Wilder's rematch with Fury should go ahead.

While Fury was able to defeat the Bronze Bomber, Joshua lost his titles to Oleksandr Usyk and lost again to the Ukrainian in last month's rematch.

That seemed to spell the end of Joshua's stint at the top of the heavyweight game but Fury has offered a shot at his WBC belt later this year, with Usyk not planning to fight until 2023 due to injuries.

Fury has made his proposals public knowledge on social media and explained why he has gone in with a 60/40 offer, while adding venues have been provisionally booked.

"I think it's more than generous. I didn't want to go in at 80/20 like they would do to me," he told TalkSport.

"I really want this fight to happen because Usyk the middleweight doesn't want no smoke like I thought he didn't and now I'm going after AJ. I've already beaten Wilder and there's only one other person and that's AJ the bodybuilder.

"Why not give him 40 per cent, no excuses, let's get the fight made for the British public. the Battle of Britain, who's going to win it, me or him?

"He only had a sparring contest [against Usyk] didn't he? He's match fit, coming off a training camp. I've seen they're trying to wriggle a bit with the dates.

"We had Manchester United football ground booked for November 12 but they're saying that's too short.

"Even better, we've got Wembley booked for November 26 and if he doesn't want that I even have December 3 in Cardiff, so take your pick you dosser."

Wembley was the venue for Fury's knockout of Dillian Whyte in April, while Cardiff played host to Joshua's 2018 victory against Joseph Parker.

Due to the winter months proposed, Cardiff's Principality Stadium may be the preferred option due to the closing roof.

The triple-header to follow the resumption of the 2022 Formula One season concludes in Italy this weekend, with Max Verstappen aiming to inflict another stinging result on Ferrari.

Back-to-back wins in Belgium and the Netherlands have seen the Red Bull ace strengthen his grip on the title, with Verstappen remarkably securing 102 out of the last 104 available – only missing out on the fastest lap in France and Hungary.

Perhaps surprisingly, Verstappen's plethora of victories in F1 have not yet included triumph on Ferrari's home soil in Italy – which has seen four different winners in each of the last four races (Lewis Hamilton in 2018, Charles Leclerc in 2019, Pierre Gasly in 2020 and Daniel Ricciardo in 2021).

While the title race looks done and dusted, Ferrari will be determined to secure bragging rights at Monza to provide a boost to a team that has sustained persistent problems this season – most recently with Carlos Sainz's woeful pit stop last weekend.

Ferrari have taken 21 pole positions in the Italian Grand Prix, more than any other team, and have won on 19 occasions – most recently with Leclerc three years ago.

The Monaco-born driver will have fond memories of that triumph and will hope it presents a platform to propel better results in the remainder of the season to at least apply some pressure to Verstappen.

Mercedes mess

Mercedes looked on course for a first victory of the season in the Netherlands last weekend, Lewis Hamilton leading the way with George Russell tucked in behind and Verstappen sitting third before a questionable call.

Russell requested a pit stop and a change for soft tyres, something that was approved and resulted in Verstappen, having also taken softs, finding himself in striking distance of Hamilton and having no problems leapfrogging his former title rival.

Hamilton was understandably furious after the race, with Mercedes fumbling what may well be their best chance of a win in 2022.

Alonso record

In his farewell stint with Alpine ahead of his move to Aston Martin for next season, Fernando Alonso is set to equal Kimi Raikkonen's record of 350 races in Formula One – with nobody else having raced in more.

That record is destined to fall Alonso's way in the future, and he could snatch another off the Finn, as his next race finish would be his 279th in Formula One – putting him ahead of Raikkonen.

Both Ons Jabeur and Caroline Garcia have made further history with their advancement to the US Open women's semi-finals on Tuesday.

The Tunisian overcame Australia's Ajla Tomljanovic in a 6-4 7-6 (7-4) victory at Arthur Ashe Stadium, before the Frenchwoman swept aside home favourite Coco Gauff 6-3 6-4.

In doing so, both have reached their first last-four appearance at the final grand slam of the year, and set themselves new benchmarks in the process.

Jabeur is the first Arab or African woman in the Open Era to make the semi-finals at Flushing Meadows.

On the back of reaching the final at Wimbledon earlier this year, she could finish the tournament as the world number two.

Garcia, meanwhile, has reached her first major semi-final without dropping a set along the way.

She has lost just 27 games en route and victory over Gauff extended her winning streak to 13.

In addition, she becomes just the third Frenchwoman to reach the US Open semi-finals in the Open Era, after Amelie Mauresmo and Mary Pierce.

Three-time Vuelta a Espana winner Primoz Roglic has withdrawn from this year's race following a crash at the end of stage 16 on Tuesday.

The Slovenian went down just 150 metres from the finish after seemingly clashing handlebars with Britain's Fred Wright (Bahrain Victorious).

Roglic had been second in the general classification, behind Remco Evenepoel, and his withdrawal leaves the Belgian with a two minute and one second lead over Enric Mas, who moves up a spot from third.

In a tweet, Roglic's team, Jumbo-Visma, stated: "Unfortunately, Primoz Roglic will not be at the start of Stage 17 as a consequence of yesterday's crash.

"Get well soon, champion! Thank you for all the beautiful moments in this Vuelta. You had ambitious plans for the final days, but sadly it isn't meant to be."

The withdrawal continues a difficult year for Roglic, who was forced to leave the Tour de France ahead of the final rest day after suffering injuries sustained in a crash with a stray hay bale on stage five.

The 2022 Vuelta a Espana concludes in Madrid on Sunday.

 #LaVuelta22

Unfortunately, @rogla will not be at the start of stage 17 as a consequence of yesterday’s crash.

Get well soon, champion! Thank you for all the beautiful moments in this Vuelta. You had ambitious plans for the final days, but sadly it isn’t meant to be. pic.twitter.com/C3Vnc8P9EO

— Team Jumbo-Visma cycling (@JumboVismaRoad) September 7, 2022

Nick Kyrgios claims all tournaments other than grand slams are a "waste of time" following his US Open quarter-final exit to Karen Khachanov on Tuesday.

The in-form 2022 Wimbledon runner-up's run at Flushing Meadows, which included knocking out defending champion Daniil Medvedev, was ended by Khachanov 7-5 4-6 7-5 6-7 (3-7) 6-4.

Kyrgios had been in career-best form, winning more matches than any other player on the ATP Tour since his Wimbledon final defeat to Novak Djokovic, but will need to wait until January for another crack at a major, at his home Australian Open.

The 27-year-old has spoken about his renewed level of focus since reaching the Wimbledon final and said he was "devastated" by his US Open loss, smashing a racquet after the match.

"I honestly feel like s***," he said. "I feel like I've let so many people down.

"I feel like these four tournaments are the only ones that are ever going to matter. It's just like you got to start it all again. I have to wait until the Australian Open. It's just devastating. It's heart-breaking.

"I don't even really care about any other tournament. I feel like at the grand slams, now having success at a grand slam, it's just like no other tournament really matters.

"It's like you get better, you get worse, then at a grand slam none of it matters. You either win or lose. People don't really care if you got better on the day or you lost 6-4 in the fifth or played one of the best matches of the tournament. You lost.

"That's all people remember at a grand slam, whether you win or you lose. I think pretty much every other tournament during the year is a waste of time really. You should just run up and show up at a grand slam. That's what you're remembered by."

Kyrgios allayed concerns over a knee injury at the end of the first set that he said settled, stating that he started "flat" and felt Khachanov's serve was too good, particularly in key moments.

"All credit to Karen, he's a fighter. He's a warrior," he said.

"I thought he served really good today. Honestly probably the best server I played this tournament, to be honest, the way he was hitting his spots under pressure."

The triumph marks 29th seed Khachanov's first major semi-final having fallen in the quarter-finals at majors twice previously.

"It's like one more step forward," the Russian said. "I'm really, really happy I could do it.

"I had to face and to beat Nick, who is playing some of the best tennis again. It obviously was a tough match to approach. I made my first semi-final, so it's pretty simple in my head. I'm just really happy."

Christian Yelich blasted the biggest home run seen in the majors since 2019 as the Milwaukee Brewers lost 10-7 to the Colorado Rockies in extras on Tuesday.

Yelich led the game off with a 499-foot home run into the third deck at Coors Field, which was also the third largest blast since Statcast started tracking homers in 2015.

Only home runs from Nomar Mazara, 505 feet in 2019, and Giancarlo Stanton, 504 in 2016, bettered Yelich's effort. Yelich's dinger came from the fourth pitch of the game from Rockies starter Chad Kuhl.

It was only one part of a thrilling contest that ended in the 10th inning with Randal Grichuk delivering a three-run home run to give the Rockies the edge.

The Rockies had trailed 6-1 going into the eighth inning before Grichek capped a five-run rally with a solo blast.

Colorado did most of their damage after Brewers starter Brandon Woodruff exited, having allowed one earned run, two hits and two walks across seven innings with five strikeouts.

Benches clear as O's edge Jays

The benches cleared as tempers flared during the seventh inning of the Baltimore Orioles' 9-6 victory over the Toronto Blue Jays.

The incident occurred after Bryan Baker struck out Matt Chapman to finish the Blue Jays innings, with the right-hander appearing to make a "chirping" signal at the Toronto dugout who took umbrage and rushed on field on masse.

The Orioles, who improve to 72-64 to boost their wild card hopes, scored three runs in the eighth inning to pull away led by Ryan Mountcastle's two-run single, with Adley Rutschman safe after review.

Mets NL setback as Cruz blasts

Oneil Cruz lined a home run out of PNC Park into the Allegheny with a two-run blast as the Pittsburgh Pirates blew out the New York Mets 8-2.

Cruz displayed his unique power from Tommy Hunter over right-field and to blast his side into an 8-2 lead.

The result is a major blow for the Mets who slip to 85-51, alongside the Atlanta Braves with the same record in the National League East.

Karen Khachanov reached a grand slam semi-final for the first time as he ended Nick Kyrgios' US Open run in a five-set three-and-a-half-hour epic on Tuesday evening.

The 27th-seeded Russian, who had fallen in the quarters at the 2019 French Open and 2021 Wimbledon Championships, prevailed 7-5 4-6 7-5 6-7 (3-7) 6-4 over the Australian 23rd seed to set up a semi-final date with fifth seed Casper Ruud.

The result ended the run of Kyrgios who had won the most matches on the ATP Tour since losing July's Wimbledon final to Novak Djokovic. Kyrgios had taken out reigning champion and top seed Daniil Medvedev in the fourth round.

The 26-year-old Russian broke Kyrgios' serve in the 12th game of the first set with an exquisite lob clinching the frame where the Australian's second serve let him down.

Kyrgios responded to win the second set, despite a medical timeout for treatment on his left leg after exclaiming "I can't walk", breaking the Russian early and hitting 12-5 winners.

Khachanov claimed the third set in similar circumstances to the first, with Kyrgios failing to hold his serve in the 12th game, this time producing unforced errors in the key moments.

The two players traded breaks early in the fourth set but Kyrgios would force a fifth set after a dominant tie-break where he converted his second set point.

The Russian got an early break in the fifth set, while Kyrgios failed to convert break points in Khachanov's next two service games and he would not recover.

Data Slam: Khachanov cool under pressure

Little split these two players in an extremely tight quarter-final, with 31-30 aces edged by Kyrgios, but many of Khachanov's came at crucial moments under pressure.

Kyrgios' flamboyance and shot-making ability was on show, but his inability to convert break points, along with 58 unforced errors, ultimately proved the difference, taking two of nine.

ACES/DOUBLE FAULTS

Kyrgios – 31/5
Khachanov – 30/3

WINNERS/UNFORCED ERRORS

Kyrgios – 75/58
Khachanov – 62/31

BREAK POINTS WON

Kyrgios – 2/9
Khachanov – 4/8

Karen Khachanov reached a grand slam semi-final for the first time as he ended Nick Kyrgios' US Open run in a five-set three-and-a-half-hour epic on Tuesday evening.

The 27th-seeded Russian, who had fallen in the quarters at the 2019 French Open and 2021 Wimbledon Championships, prevailed 7-5 4-6 7-5 6-7 (3-7) 6-4 over the Australian 23rd seed.

The result ended the run of Kyrgios who had won the most matches on the ATP Tour since losing July's Wimbledon final to Novak Djokovic. Kyrgios had taken out reigning champion and top seed Daniil Medvedev in the fourth round.

The 26-year-old Russian broke Kyrgios' serve in the 12th game of the first set with an exquisite lob clinching the frame where the Australian's second serve let him down.

Kyrgios responded to win the second set, despite a medical timeout for treatment on his left leg after exclaiming "I can't walk", breaking the Russian early and hitting 12-5 winners.

Khachanov claimed the third set in similar circumstances to the first, with Kyrgios failing to hold his serve in the 12th game, this time producing unforced errors in the key moments.

The two players traded breaks early in the fourth set but Kyrgios would force a fifth set after a dominant tie-break where he converted his second set point.

The Russian got an early break in the fifth set, while Kyrgios failed to convert break points in Khachanov's next two service games and he would not recover.

Data Slam: Khachanov cool under pressure

Little split these two players in an extremely tight quarter-final, with 31-30 aces edged by Kyrgios, but many of Khachanov's came at crucial moments under pressure.

Kyrgios' flamboyance and shot-making ability was on show, but his inability to convert break points, along with 58 unforced errors, ultimately proved the difference, taking two of nine.

ACES/DOUBLE FAULTS

Kyrgios – 31/5
Khachanov – 30/3

WINNERS/UNFORCED ERRORS

Kyrgios – 75/58
Khachanov – 62/31

BREAK POINTS WON

Kyrgios – 2/9
Khachanov – 4/8